Congratulations to Dr. Menegatti and Dr. Carbonell for receiving $60,000 from the Chancellor’s Innovation Fund. This fund will go towards the development and commercialization of a novel technology for purification of therapeutic monoclonal antibodies. The initial work is summed in these two articles: “Targeted Capture of Chinese Hamster Ovary Host Cell Proteins: Peptide Ligand Discovery” and “Targeted capture of Chinese hamster ovary host cell proteins: Peptide ligand binding by proteomic analysis.”
Congratulations to Ashton for passing her defense!
Huge congratulations to Ashton Lavoie for passing her doctoral thesis defense. She is the first one in the lab to complete her PhD. The title of her thesis was “Capture of Chinese Hamster Ovary Host Cell Proteins from Therapeutic Monoclonal Antibody Production Harvest by Mixed-Mode Synthetic Ligands.” Moving forward she will be working at BridgeBio Gene Therapy as a process development scientist. Way to go Ashton, we are all so proud of you!
New $27 Million Grant
$27M funding to Focus on the Future of Biomanufacturing
Dr. Stefano Menegatti and Dr. Ruben Carbonell will lead a new 5-year project funded by the Novo Nordisk Foundation. The project, “Accelerated Innovation in Manufacturing Biologics (AIM-Bio),” focuses on the developing nine new novel technologies of biopharmaceutical manufacturing including: cell factory engineering, bioreactor designs and optimization of purification of biopharmaceutical products. NC State will receive $18 million to carry out its research, and the remainder will go to Technical University of Denmark (DTU). To read more about the project click here.
New Paper Published
Great job to everyone in the lab continuing to get new papers published. The newest paper in the lab includes graduate student Hannah Reese, undergraduate student Calvin Shanahan, and Dr. Stefano Menegatti. The title is “Translating Antibody-Binding Peptides into Peptide Ligands with Improved Affinity and Stability.” Be sure to go check it out here!
Dr. Menegatti received a new patent!
We are so proud of Dr. Menegatti’s work that has gone into his new patent for Protease Resistant Peptide Ligands. Congrats!
Go check out the patent here
New Paper published!
Congrats to Dr. Menegatti, Ashton Lavoie, Raphael Prodromou, and Kevin day on their new paper. Go check it out!
https://www.nature.com/articles/s41598-019-42869-5
New Paper Published
Congratulations to Ashton Lavoie for having her manuscript published in the International Journal of Molecular Sciences. Go check it out!
Great Job to Our Presenters at ACS
Great job to everyone who gave a talk and/or presented a poster at the ACS conference last weekend!
Kaitlyn Bacon –
- Talk: Screening yeast display libraries against magnetized yeast cell targets enables efficient isolation of membrane protein binders
Ashton Lavoie –
- Poster: Mixed-mode peptide ligands for improved clearance of CHO host cell proteins
Hannah Reese –
- Talk: Toward a true Protein A mimetic: new peptide affinity for IgG purification afford high HCP LRV
- Poster: Mechanically controlled thermodynamics of biorecognition events
John Schneible –
- Talk: Integrated approach for tailoring chitosan hydrogels towards kinetically-tuned release of synergistic combinations of chemotherapeutics
- Talk: Tuning the surface chemistry of graphene oxide nanoparticles for controlling drug release: modeling and experiments
Srivatsan Ramesh Presents at TechTextil North America 2019
Srivatsan Ramesh recently presented his work on self-repairing nonwovens using stimuli responsive microgels. The talk was given at the TechTextil North America 2019 to an industrial and academic audience. He talked about designing microgel systems that help replicate the blood clotting mechanism in our bodies into nonwoven systems.
This research has been funded by The Nonwovens Institute here at NC State.
Postdoc Positions in the Menegatti/Carbonell Lab
The Menegatti/Carbonell lab in the Department of Chemical & Biomolecular Engineering at North Carolina State University is seeking TWO postdoctoral candidates for a project on the removal of host-cell protein (HCPs) impurities from MAb-containing cell culture fluids in flow-through mode. The postdoctoral scholars will work on developing novel multi-modal ligands and adsorbents, as well as assembling and optimizing a continuous process for HCP removal in flow-through mode. Process development will involve (i) preparing the needed adsorbents, (ii) combining them in a process, and (iii) characterizing process performance with current bioassays and proteomics by mass spectrometry.